Causes of Parkinson's Disease

Normal movement depends on the appropriate production of a chemical messenger or ‘neurotransmitter’ called dopamine by cells in an area of the brain called the substantia nigra (Figure 1). In people with Parkinson’s disease, the cells in this part of the brain begin to lose their ability to produce this chemical messenger. When a major proportion of the dopamine-producing cells have stopped working, the symptoms of Parkinson’s disease start to appear.   

The reason why these dopamine-producing brain cells stop working is still unknown. Scientists think that certain people may have an inherited susceptibility to develop Parkinson’s disease. Other causes, such as environmental effects, have also been tentatively suggested as causes of the condition; however, none of these have been fully confirmed yet4.

Brain diagram


Figure 1. In Parkinson’s disease, dopamine-producing cells in the brain degenerate

 

 
 
RSS
Follow Us
#Parkinsons 'Deep Brain Stimulation': Read Briony's latest blog http://t.co/ncomJIgmxv
@wearingoff   |   2 days ago
#Parkinsons Jill was diagnosed with Parkinsons in May 1997. She talks us through the 16 years since her diagnosis http://t.co/6IU5JgS33v
@wearingoff   |   3 days ago
#Parkinsons The free tools on the WO site can help you give your doctor valuable information about your PD symptoms http://t.co/CFYe1MRBIM
@wearingoff   |   4 days ago

You are now leaving the Wearing Off website, moving to an external website independently operated and not managed by Orion. Orion assumes no responsibility for these sites.

If you do not wish to leave this site, click Cancel. Click Continue to leave the site.

Continue | Cancel

Disclaimer Text



You are now leaving the Global site WearingOff.com and are about to enter the German site WearingOff.de.

These sites are similar in content, but there have been adaptations to accommodate linguistic differences and country specific regulatory requirements.

Disclaimer Text



You are now leaving the Global site WearingOff.com and are about to enter the UK site WearingOff.co.uk.

These sites are similar in content, but there have been adaptations to accommodate linguistic differences and country specific regulatory requirements.

Disclaimer Text



You are now leaving the Global site WearingOff.com and are about to enter the Finnish site WearingOff.fi.

These sites are similar in content, but there have been adaptations to accommodate linguistic differences and country specific regulatory requirements.

Disclaimer Text



You are now leaving the Global site WearingOff.com and are about to enter the Russian site WearingOff.ru.

These sites are similar in content, but there have been adaptations to accommodate linguistic differences and country specific regulatory requirements.

Disclaimer Text



You are now leaving the Global site WearingOff.com and are about to enter the Swedish site WearingOff.se.

These sites are similar in content, but there have been adaptations to accommodate linguistic differences and country specific regulatory requirements.

#Parkinsons 'Deep Brain Stimulation': Read Briony's latest blog http://t.co/ncomJIgmxv